Blar i forfatter "Michelsen, Annika Elisabet"

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    • Anti-PF4/polyanion antibodies in COVID-19 patients are associated with disease severity and pulmonary pathology 

      Ueland, Thor; Sørvoll, Ingvild Hausberg; Mørtberg, Trude Victoria; Dahl, Tuva Børresdatter; Lerum, Tøri Vigeland; Michelsen, Annika Elisabet; Ranheim, Trine; Nezvalova-Henriksen, Katerina; Dyrhol-Riise, Anne Ma; Holme, Pål Andre; Aaløkken, Trond Mogens; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Ahlen, Maria Therese; Aukrust, Pål; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-02-28)
      Thromboembolic events are frequent and associated with poor outcome in severe COVID-19 disease. Anti-PF4/polyanion antibodies are related to heparin-induced thrombocytopenia (HIT) and thrombus formation, but data on these antibodies in unselected COVID-19 populations are scarce. We assessed the presence of anti-PF4/polyanion antibodies in prospectively collected serum from an unselected cohort ...

    • Breakthrough infections with the omicron and delta variants of SARS-CoV-2 result in similar re-activation of vaccine-induced immunity 

      Søraas, Arne Vasli; Grødeland, Gunnveig; Granerud, Beathe Kiland; Ueland, Thor; Lind, Andreas; Fevang, Børre; Murphy, Sarah Louise Mikalsen; Huse, Camilla; Nygaard, Anders Benteson; Steffensen, Anne Katrine; Al-Baldawi, Huda; Holberg-Petersen, Mona; Andresen, Lise Lima; Ågnes, Camilla; Ranheim, Trine; Schanke, Ylva; Istre, Mette Stausland; Dahl, John Arne; Chopra, Adity; Dudman, Susanne; Kaarbø, Mari; Andersen, Jan Terje; Vaage, Eline Benno; Tran, Trung The; Vaage, John Torgils; Michelsen, Annika Elisabet; Müller, Fredrik; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Holter, Jan Cato; Lund-Johansen, Fridtjof (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-09-08)
      Background: Results showing that sera from double vaccinated individuals have minimal neutralizing activity against Omicron have been interpreted as indicating the need for a third vaccine dose for protection. However, there is little information about early immune responses to Omicron infection in double vaccinated individuals.<p> <p>Methods: We measured inflammatory mediators, antibodies to the ...

    • Circulating markers of extracellular matrix remodelling in severe COVID-19 patients 

      Murphy, Sarah Louise Mikalsen; Halvorsen, Bente; Holter, Jan Cato; Huse, Camilla; Tveita, Anders; Trøseid, Marius; Hoel, Hedda; Kildal, Anders Benjamin; Holten, Aleksander Rygh; Lerum, Tøri Vigeland; Skjønsberg, Ole Henning; Michelsen, Annika Elisabet; Aaløkken, Trond Mogens; Tonby, Kristian; Lind, Andreas; Dudman, Susanne Gjeruldsen; Granerud, Beathe Kiland; Heggelund, Lars; Bøe, Simen; Dyrholt-Riise, Anne Ma; Aukrust, Pål; Barratt-Due, Andreas; Ueland, Thor; Dahl, Tuva Børresdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-09-17)
      Background Abnormal remodelling of the extracellular matrix (ECM) has generally been linked to pulmonary inflammation and fibrosis and may also play a role in the pathogenesis of severe COVID-19. To further elucidate the role of ECM remodelling and excessive fibrogenesis in severe COVID-19, we examined circulating levels of mediators involved in various aspects of these processes in COVID-19 ...

    • Coagulopathy and adverse outcomes in hospitalized patients with COVID-19: results from the NOR-Solidarity trial 

      Ueland, Thor; Michelsen, Annika Elisabet; Tveita, Anders; Kåsine, Trine; Dahl, Tuva Børresdatter; Finbråten, Ane-Kristine; Holten, Aleksander Rygh; Skjønsberg, Ole Henning; Mathiessen, Alexander; Nezvalova-Henriksen, Katerina; Trøseid, Marius; Aaløkken, Trond Mogens; Halvorsen, Bente; Dyrhol-Riise, Anne Ma; Barratt-Due, Andreas; Aukrust, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-12-07)
      Background - Several studies have examined parameters of increased thrombogenicity in COVID-19, but studies examining their association with long-term outcome and potential effects of antiviral agents in hospitalized patients with COVID-19 are scarce.<p> <p>Objectives - To evaluate plasma levels of hemostatic proteins during hospitalization in relation to disease severity, treatment modalities, ...

    • Complement factors B, D, C3bBbP and risk of future venous thromboembolism 

      Skjeflo, Espen Waage; Evensen, Line Holtet; Jensen, Søren Beck; Latysheva, Nadezhda; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid Kufaas; Hindberg, Kristian Dalsbø; Snir, Omri; Mollnes, Tom Eirik; Hansen, John Bjarne (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-03-07)
      The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE).<p> <p>We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured at inclusion, with the risk of future VTE in a nested case-control study; 380 VTE patients and 804 age- and sex-matched controls derived from the Tromsø study. Odds ratios ...

    • The Effect of Protease-Activated Receptor-1 (PAR-1) Inhibition on Endothelial-Related Biomarkers in Patients with Coronary Artery Disease 

      Nilsen, Dennis W.T.; Røysland, Michelle; Ueland, Thor; Aukrust, Pål; Michelsen, Annika Elisabet; Staines, Harry; Barvik, Ståle; Kontny, Frederic; Nordrehaug, Jan Erik; Bonarjee, Vernon V S (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-20)
      Abstract Background: Vorapaxar has been shown to reduce cardiovascular mortality in postmyocardial infarction (MI) patients. Pharmacodynamic biomarker research related to protease-activated receptor-1 (PAR-1) inhibition with vorapaxar in humans has short follow-up (FU) duration and is mainly focused on platelets rather than endothelial cells. Aim: This article assesses systemic changes in ...

    • Elevated plasma D-dimer levels are associated with risk of future incident venous thromboembolism 

      Hansen, Ellen-Sofie; Rinde, Fridtjof Balteskard; Edvardsen, Magnus; Hindberg, Kristian; Latysheva, Nadezhda; Aukrust, Pål; Ueland, Thor; Michelsen, Annika Elisabet; Hansen, John Bjarne; Brækkan, Sigrid Kufaas; Morelli, Vania Maris (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-25)
      <p><i>Background</i> D-dimer, a global biomarker for activation of the coagulation and fibrinolysis systems, is useful in assessing individual risk of venous thromboembolism (VTE) recurrence. However, there is limited information on the association between D-dimer and risk of a first lifetime VTE event. <p><i>Objectives</i> To investigate the association between plasma D-dimer levels and risk of ...

    • Hepcidin predicts 5-year mortality after community-acquired pneumonia 

      Oppen, Kjersti; Ueland, Thor; Michelsen, Annika Elisabet; Aukrust, Pål; Steinsvik, Trude; Skadberg, Øyvind; Brede, Cato; Siljan, William Ward; Husebye, Einar; Holter, Jan Cato; Heggelund, Lars (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-01-20)
      Background: Virtually all living organisms, including microbes and humans, depend on iron to survive and grow. During an infection, the plasma level of iron and several iron-related proteins change substantially. We hypothesized that iron and iron-related proteins could predict short- and long-term outcomes in community-acquired pneumonia.<p> <p>Methods: Blood samples from a prospective cohort ...

    • High circulating levels of the homeostatic chemokines CCL19 and CCL21 predict mortality and disease severity in Covid-19 

      Tveita, Anders Aune; Murphy, Sarah Louise Mikalsen; Holter, Jan Cato; Kildal, Anders Benjamin; Michelsen, Annika Elisabet; Lerum, Tøri Vigeland; Kaarbø, Mari; Heggelund, Lars; Holten, Aleksander Rygh; Finbråten, Ane-Kristine; Muller, Karl Erik; Mathiessen, Alexander; Bøe, Simen; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Lind, Andreas; Dudman, Susanne; Nezvalova-Henriksen, Katerina; Müller, Fredrik; Skjønsberg, Ole Henning; Trøseid, Marius; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Dahl, Tuva Børresdatter; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-25)
      Background. Immune dysregulation is a major factor in the development of severe coronavirus disease 2019 (COVID-19). The homeostatic chemokines CCL19 and CCL21 have been implicated as mediators of tissue inflammation, but data on their regulation in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is limited. We thus investigated the levels of these chemokines in COVID-19 ...

    • IL-18 and IL-18 binding protein are related to disease severity and parasitemia during falciparum malaria 

      Otterdal, Kari; Berg, Åse; Michelsen, Annika Elisabet; Yndestad, Arne; Patel, Sam; Gregersen, Ida; Halvorsen, Bente; Ueland, Thor; Langeland, Nina; Aukrust, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-10-18)
      Background - Several inflammatory molecules participate in the immune response to malaria. Interleukin (IL)-18 is an inflammatory cytokine activated by NLRP3 inflammasomes. In clinical falciparum malaria, with and without HIV co-infection, data on IL-18 and in particular on its binding protein, IL-18bp, is scarce.<p> <p>Methods - Clinical data and blood samples were collected from adults in ...

    • Immune complexes, innate immunity, and NETosis in ChAdOx1 vaccine-induced thrombocytopenia 

      Holm, Sverre; Kared, Hassen; Michelsen, Annika Elisabet; Kong, Xiang Yi; Dahl, Tuva Børresdatter; Schultz, Nina Haagenrud; Nyman, Tuula Anneli; Fladeby, Cathrine; Seljeflot, Ingebjørg; Ueland, Thor; Stensland, Maria; Mjaaland, Siri; Goll, Guro Løvik; Nissen-Meyer, Lise Sofie Haug; Aukrust, Pål; Skagen, Karolina Ryeng; Gregersen, Ida; Skjelland, Mona; Holme, Pål Andre; Munthe, Ludvig Andre; Halvorsen, Bente (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-18)
      Aims - We recently reported five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) 7–10 days after receiving the first dose of the ChAdOx1 nCoV-19 adenoviral vector vaccine against corona virus disease 2019 (COVID-19). We aimed to investigate the pathogenic immunological responses operating in these patients.<p> <p>Methods and results - We assessed circulating inflammatory markers ...

    • Impact of a Vancomycin-Induced Shift of the Gut Microbiome in a Gram-Negative Direction on Plasma Factor VIII:C Levels: Results from a Randomized Controlled Trial 

      Grimnes, Gro; Bhoelan, Soerajja; Hindberg, Kristian; Davids, Mark; Nieuwdorp, Max; Mollnes, Tom E.; Michelsen, Annika Elisabet; Ueland, Thor; Brækkan, Sigrid K.; Hansen, John-Bjarne; Tichelaar, Ynse Ieuwe Gerardus Vladimir (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-08-24)
      Rationale - Inflammation is present in several conditions associated with risk of venous thromboembolism. The gut microbiome might be a source of systemic inflammation and activation of coagulation, by translocation of lipopolysaccharides from gram-negative bacteria to the systemic circulation.<p> <p>Objective - To investigate whether a vancomycin-induced shift of the gut microbiome in a gram-negative ...

    • The inflammatory response is related to circulatory failure after out-of-hospital cardiac arrest: A prospective cohort study 

      Langeland, Halvor Johannes Breivik; Damås, Jan Kristian; Mollnes, Tom Eirik; Ludviksen, Judith K; Ueland, Thor; Michelsen, Annika Elisabet; Løberg, Magnus; Bergum, Daniel; Nordseth, Trond; Skjærvold, Nils Kristian; Klepstad, Pål (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-11-24)
      Background: Whole body ischemia and reperfusion injury after cardiac arrest leads to the massive inflammation clinically manifested in the post-cardiac arrest syndrome. Previous studies on the inflammatory effect on circulatory failure after cardiac arrest have either investigated a selected patient group or a limited part of the inflammatory mechanisms. We examined the association between cardiac ...

    • Interleukin-6 inhibition in ST-elevation myocardial infarction: Immune cell profile in the randomised ASSAIL-MI trial 

      Huse, Camilla; Anstensrud, Anne Kristine; Michelsen, Annika Elisabet; Ueland, Thor; Broch, Kaspar; Woxholt, Sindre; Yang, Kuan; Sharma, Kapil Kishore; Tøllefsen, Ingvild Maria; Bendz, Bjørn; Amundsen, Brage H.; Damås, Jan Kristian; Berg, Erlend Sturle; Bjørkelund, Elisabeth; Quiles-Jiménez, Ana M T; Bjerkeli, Vigdis; Bendz, Christina; Kleveland, Ola; Stensæth, Knut Haakon; Opdahl, Anders; Kløw, Nils-Einar; Andersen, Geir Øystein; Wiseth, Rune; Halvorsen, Bente; Gullestad, Lars; Seljeflot, Ingebjørg; Aukrust, Pål; Osnes, Liv T. N.; Dahl, Tuva Børresdatter (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-04-30)
      Background We recently showed that interleukin (IL)-6 inhibition by tocilizumab improves myocardial salvage in ST-elevation myocardial infarction (STEMI). However, the mechanisms for this effect are not clear.<p> <p>Methods In this exploratory sub-study of the ASSAIL-MI trial, we examined leukocyte differential counts and their relation to myocardial salvage and peak troponin T (TnT) in STEMI ...

    • Intestinal injury in cardiac arrest is associated with multiple organ dysfunction: A prospective cohort study 

      Farbu, Bjørn Hoftun; Langeland, Halvor; Ueland, Thor; Michelsen, Annika Elisabet; Krüger, Andreas Jørstad; Klepstad, Pål; Nordseth, Trond (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-02-25)
      Background - The impact of intestinal injury in cardiac arrest is not established. The first aim of this study was to assess associations between clinical characteristics in out-of-hospital cardiac arrest (OHCA) and a biomarker for intestinal injury, Intestinal Fatty Acid Binding Protein (IFABP). The second aim was to assess associations between IFABP and multiple organ dysfunction and 30-day ...

    • Lasting Immunological Imprint of Primary Epstein-Barr Virus Infection With Associations to Chronic Low-Grade Inflammation and Fatigue 

      Fevang, Børre; Wyller, Vegard Bruun Bratholm; Mollnes, Tom Eirik; Pedersen, Maria; Asprusten, Tarjei Tørre; Michelsen, Annika Elisabet; Ueland, Thor; Otterdal, Kari (Journal article; Tidsskriftartikkel; Peer reviewed, 2021-12-20)
      Background: Epstein-Barr virus (EBV) causes infectious mononucleosis (IM) that can lead to chronic fatigue syndrome. The CEBA-project (Chronic fatigue following acute EBV infection in Adolescents) has followed 200 patients with IM and here we present an immunological profiling of adolescents with IM related to clinical characteristics.<p> <p>Methods: Patients were sampled within 6 weeks of debut ...

    • Markers of extracellular matrix remodeling and systemic inflammation in patients with heritable thoracic aortic diseases 

      Seim, Bjørn Edvard; Holt, Margrethe Flesvig; Ratajska, Aleksandra; Michelsen, Annika Elisabet; Ringseth, Monica Myklebust; Halvorsen, Bente; Skjelland, Mona; Kvitting, John-Peder; Lundblad, Runar; Krohg-Sørensen, Kirsten; Osnes, Liv T. N.; Aukrust, Pål; Paus, Benedicte; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-12-20)
      Background: In approximately 20% of patients with thoracic aortic aneurysms or dissections a heritable thoracic aortic disease (HTAD) is suspected. Several monogenic connective tissue diseases imply high risk of aortic disease, including both non-syndromic and syndromic forms. There are some studies assessing inflammation and extracellular matrix remodeling in patients with non-hereditary aortic ...

    • Persistent T-cell exhaustion in relation to prolonged pulmonary pathology and death after severe COVID-19: Results from two Norwegian cohort studies 

      Trøseid, Marius; Dahl, Tuva Børresdatter; Holter, Jan Cato; Kildal, Anders Benjamin; Murphy, Sarah Louise Mikalsen; Yang, Kuan; Quiles Jimenez, Ana Maria Teresa; Heggelund, Lars; Muller, Karl Erik; Tveita, Anders Aune; Michelsen, Annika Elisabet; Bøe, Simen; Holten, Aleksander Rygh; Hoel, Hedda Benedicte; Mathiessen, Alexander; Aaløkken, Trond Mogens; Fevang, Børre; Granerud, Beathe Kiland; Tonby, Kristian; Nezvalova-Henriksen, Katerina; Lerum, Tøri Vigeland; Müller, Fredrik; Skjønsberg, Ole Henning; Barratt-Due, Andreas; Riise, Anne Margarita Dyrhol; Aukrust, Pål; Halvorsen, Bente Evy; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-08-18)
      Background - T-cell activation is associated with an adverse outcome in COVID-19, but whether T-cell activation and exhaustion relate to persistent respiratory dysfunction and death is unknown.<p> <p>Objectives - To investigate whether T-cell activation and exhaustion persist and are associated with prolonged respiratory dysfunction and death after hospitalization for COVID-19.<p> <p>Methods ...

    • Platelet and mitochondrial RNA is decreased in plasma-derived extracellular vesicles in women with preeclampsia—an exploratory study 

      Lekva, Tove; Sundaram, Arvind; Roland, Marie Cecilie; Åsheim, June; Michelsen, Annika Elisabet; Norwitz, Errol R.; Aukrust, Pål; Gilfillan, Gregor; Ueland, Thor (Journal article; Tidsskriftartikkel; Peer reviewed, 2023-11-23)
      Background - Circulating extracellular vesicles (EVs) are increased in preeclampsia (PE) and are associated with severity and progression. We examined in this exploratory cohort study if the mRNAs and long noncoding RNAs (lncRNAs) in plasma-derived EVs were dysregulated in PE compared to normal pregnancy and display different temporal patterns during gestation.<p> <p>Methods - We isolated EVs ...

    • Raised Serum Markers of T Cell Activation and Exhaustion in Granulomatous-Lymphocytic Interstitial Lung Disease in Common Variable Immunodeficiency 

      Fraz, Mai Sasaki Aanensen; Michelsen, Annika Elisabet; Moe, Natasha; Aaløkken, Trond Mogens; Macpherson, Magnhild Eide; Nordøy, Ingvild; Aukrust, Pål; Taraldsrud, Eli; Holm, Are Martin; Ueland, Thor; Jørgensen, Silje Fjellgård; Fevang, Børre (Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-05)
      Purpose About 20–30% of patients with common variable immunodefciency (CVID) develop granulomatous-lymphocytic interstitial lung disease (GLILD) as one of several non-infectious complications to their immunodefciency. The purpose of this study was to identify biomarkers that could distinguish GLILD from other non-infectious complications in CVID.<p> <p>Methods We analyzed serum biomarkers related ...